5-Isocyanato-1,3-dioxaindane → 1-(1,3-benzodioxol-5-yl)-3-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-dibenzo[de,h]isoquinolin-8-yl}urea

関与物質

反応条件

反応手順

A solution of 100 mg (0.30 mmole) of 8-amino-2-[2-(dimethylamino)ethyl]-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione (obtained in example 4) in 4 mL of acetonitrile was stirred at 20° C. 3,4-(methylenedioxy)phenyl isocyanate (4 molar equivalents) in 3 mL acetonitrile were added. The mixture was magnetically stirred at 20° C. during 24 hours. The solvent was then evaporated under reduced pressure and the residue was submitted to a flash chromatography on silica (eluent: CH2Cl2/methanol in a 95:5 volume ratio) to provide 76 mg (yield: 51%). of the desired product (formula below) as an orange powder

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