3-Furanol, tetrahydro- → 2-Methyl-4-(tetrahydro-furan-3-yloxy)-8-(2,4,6-trimethyl-phenyl)-quinoline

HRID 1813917ノート

反応式

HRID 1813917 の反応式
[OH:1][CH:2]1[CH2:6][CH2:5][O:4][CH2:3]1.Cl[C:8]1[C:17]2[C:12](=[C:13]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([CH3:25])=[CH:20][C:19]=3[CH3:26])[CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([CH3:27])[CH:9]=1>>[CH3:27][C:10]1[CH:9]=[C:8]([O:1][CH:2]2[CH2:6][CH2:5][O:4][CH2:3]2)[C:17]2[C:12](=[C:13]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([CH3:25])=[CH:20][C:19]=3[CH3:26])[CH:14]=[CH:15][CH:16]=2)[N:11]=1

参加物

3

反応物 2

HCID 99603-Furanol, tetrahydro-HCID 225043522-Methyl-4-chloro-8-(2,4,6-trimethylphenyl)-quinoline

生成物 1

HCID 104728832-Methyl-4-(tetrahydro-furan-3-yloxy)-8-(2,4,6-trimethyl-phenyl)-quinoline

実験手順

The title compound was prepared as a light yellow solid starting from 3-hydroxytetrahydrofuran and 4-chloro-2-methyl-8-(2,4,6-trimethyl-phenyl)-quinoline using procedure analogous to that described in Example 5. 1H NMR (CDCl3) δ 8.17(d,1H), 7.39-7.46(m,2H), 6.96(s,2H), 6.49(s,1H), 5.13(m,1H), 4.14(d,2H), 3.8-4.1(m,4H), 2.51(s,3H), 2.36(s,3H), 2.15-2.20(m,2H), 1.89(s,6H)ppm.

出典と根拠

ORDレコード
ord-db60b3e660f14d2284a76f7b80afff74
出典データセット
uspto-grants-2005_04
特許番号
US06875769B2

反応ノート

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