Hydrochloric Acid → HCID 11717794、化合物

HRID 1813928ノート

反応式

HRID 1813928 の反応式
[CH2:1]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:12][N:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[C:22]([O:26][CH2:27][CH3:28])(=[O:25])[CH:23]=[CH2:24]>CCOC(C)=O>[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][CH2:14][CH:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][N:11]1[CH2:24][CH2:23][C:22]([O:26][CH2:27][CH3:28])=[O:25])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 10989367Ethyl 2-Benzyloxymethyl-5-pyridinecarboxylate

生成物 1

HCID 11717794HCID 11717794、化合物収率 13%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
80 °C

実験手順

To an EtOAc solution (0.9 mL) of 14c (271 mg, 1.0 mmol) was added 2 M ethereal HCl (3.6 mL), and then the solvent was removed in vacuo and the residual 14c.HCl salt was dissolved in MeOH (5.4 mL) and PtO2 (14 mg) was added. The mixture was hydrogenated under 1 atm of H2 (1 h). The catalyst was filtered, and the solvent was removed in vacuo. The residue was dissolved in aqueous 1 N NaOH (3.5 mL) and extracted with EtOAc (3×15 mL). The organic extracts were combined, dried (Na2SO4), concentrated, and then dissolved in ethyl acrylate (1.1 mL, 10 mmol) and stirred at 80° C. (20 h). The reaction was concentrated to dryness and the residue was separated by PTLC (EtOAc/hexanes=2/3) to give 15c (48 mg, 13%) and 17 (32 mg, 12%), respectively. Compound 15c: clear oil; Rf 0.57 (EtOAc/hexanes=1/1); IR (neat) 2978, 2935, 2862, 1731, 1454, 1372, 1181 cm−1; 1H NMR (CDCl3) δ 1.24 (t, J=7.2 Hz, 3H), 1.25 (t, J=7.2 Hz, 3H), 1.64-1.77 (m, 4H), 2.43-2.54 (m, 3H), 2.66 (dd, J=3.9, 12.2 Hz, 1H), 2.82-2.97 (m, 4H), 3.45 (dd, J=5.9, 9.6 Hz, 1H), 3.66 (dd, J=5.4, 9.6 Hz, 1H), 4.12 (q, J=7.2 Hz, 4H), 4.47 (1/2 AB, J=12.2 Hz, 1H), 4.52 (1/2 AB, J=12.2 Hz, 1H), 7.27-7.34 (m, 5H), 13C NMR (CDCl3) 14.1, 14.2, 23.3, 25.9, 33.1, 40.6, 50.1, 50.3, 57.6, 60.1, 60.2, 69.3, 73.2, 127.4, 127.5 (2C), 128.3 (2C), 138.3, 172.7, 174.1 ppm; MS (+CI) 378 [M+1]+; Mr (+CI) 378.228 63 [M+1]+ (calcd for C21H32NO5 378.228 05). Compound 17 (King et al., “Substituted Benzamides with Conformationally Restricted Side Chains. 5. Azabicyclo[xyz] Derivatives as 5-HT4 Receptor Agonists and Gastric Motility Stimulants”, J. Med. Chem. 1993, 36, 683-689) (cis- and trans-mixture): yellow oil; Rf 0.44 (EtOAc/hexanes=1/1); IR (neat) 2974, 2924, 2814, 1735, 1455, 1377 cm−1; 1H NMR (CDCl3) δ 1.00 (d, J=6.6 Hz, 1.4H), 1.10 (d, J=6.6 Hz, 1.6H), 1.23-1.28 (m, 6H), 1.40-2.01 (m, 4H), 2.18-2.31 (m, 1H), 2.42-2.59 (m, 4H), 2.67-2.88 (m, 2H), 3.03-3.10 (m, 1H), 4.08-4.17 (m, 4H), 13C NMR (CDCl3) 13.7 (2C), 14.2 (2C), 19.9 (2C), 23.1 (2C), 27.4 (2C), 32.7, 33.8, 41.2, 42.2, 48.8, 49.6, 49.8, 53.3, 54.1, 55.1, 60.2 (2C), 60.3 (2C), 172.8 (2C), 174.1 (2C) ppm; MS (+CI) 272 [M+1]+; Mr (+CI) 272.186 63 [M+1]+ (calcd for C14H26NO4 272.186 18).

後処理

  1. customthe solvent was removed in vacuo
  2. dissolutionHCl salt was dissolved in MeOH (5.4 mL)
  3. additionPtO2 (14 mg) was added
  4. customwas hydrogenated under 1 atm of H2 (1 h)
  5. filtrationThe catalyst was filtered
  6. customthe solvent was removed in vacuo
  7. dissolutionThe residue was dissolved in aqueous 1 N NaOH (3.5 mL)
  8. extractionextracted with EtOAc (3×15 mL)
  9. dry with materialdried (Na2SO4)
  10. concentrationconcentrated
  11. concentrationThe reaction was concentrated to dryness
  12. customthe residue was separated by PTLC (EtOAc/hexanes=2/3)

出典と根拠

ORDレコード
ord-13bb5bf7f5c74a50a6036fa427c69711
出典データセット
uspto-grants-2005_04
特許番号
US06875774B2

反応ノート

読み込み中…