HCID 20770807、化合物 → 2-[3-Methoxy-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenyl]-2-methyl-propionic acid methyl ester

HRID 1814165ノート

反応式

HRID 1814165 の反応式
[CH3:1][O:2][C:3](=[O:33])[C:4]([C:7]1[CH:12]=[CH:11][C:10]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23]N=3)=[CH:17][CH:16]=2)=[C:9]([O:31][CH3:32])[CH:8]=1)([CH3:6])[CH3:5].[CH3:34]OC(=O)C(C1C=CC(S)=C(OC)C=1)(C)C>>[CH3:1][O:2][C:3](=[O:33])[C:4]([C:7]1[CH:12]=[CH:11][C:10]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:34]=[CH:23][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:25][CH:26]=3)=[CH:17][CH:16]=2)=[C:9]([O:31][CH3:32])[CH:8]=1)([CH3:6])[CH3:5]

参加物

3

反応物 2

HCID 20770807HCID 20770807、化合物HCID 207708082-(4-Mercapto-3-methoxy-phenyl)-2-methyl propionic acid methyl ester

生成物 1

HCID 207708062-[3-Methoxy-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenyl]-2-methyl-propionic acid methyl ester収率 34%

実験手順

Compound 47A was prepared analogously to compound 21D using the product prepared from compound 21C. Yield was 34% after flash column purification. MS m/z 475 (M+1).

後処理

  1. customYield was 34% after flash column purification

出典と根拠

ORDレコード
ord-b387db04f4744390884ceef77ff681df
出典データセット
uspto-grants-2005_04
特許番号
US06875780B2

反応ノート

読み込み中…