Thenyl mercaptan → 4-[[(1R)-2-Hydroxy-1-methylethyl]amino]-2-[[(2-thienyl)methyl)thio]-7(8H)-pteridinone

反応式

F[C:2]1[C:7](F)=[CH:6]C=C[C:3]=1[CH2:9][S:10]([C:13]1[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=1)(=O)=O.[S:29]1C=CC=C1CS>>[OH:26][CH2:25][C@H:24]([NH:23][C:21]1[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=[C:13]([S:10][CH2:9][C:3]2[S:29][CH:6]=[CH:7][CH:2]=2)[N:22]=1)[CH3:27]

参加物

反応物 2

HCID 80408Thenyl mercaptan

HCID 688171932-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

生成物 1

HCID 688161344-[[(1R)-2-Hydroxy-1-methylethyl]amino]-2-[[(2-thienyl)methyl)thio]-7(8H)-pteridinone収率 56.6%

実験手順

The titled compound (0.076 g) was prepared by the method of Example 13, step (c) using the product from Example 13, step (a) (0.20 g) and 2-thienylmethylmercaptan (0.050 g).

出典と根拠

ORDレコード: ord-d3f943080c764ce791996fb26068098b
出典データセット: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06875868B2

反応ノート

読み込み中…