Hydrochloric Acid → 2-Amino-1-(morpholin-4-yl)ethan-1-one--hydrogen chloride (1/1)

HRID 1814740ノート

反応式

HRID 1814740 の反応式
C(OC(=O)[NH:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])(C)(C)C.[ClH:18]>O1CCOCC1>[ClH:18].[NH2:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 10538259tert-Butyl [2-(morpholin-4-yl)-2-oxoethyl]carbamate

生成物 1

HCID 122918142-Amino-1-(morpholin-4-yl)ethan-1-one--hydrogen chloride (1/1)収率 76%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a stirred solution of the above (2-morpholin-4-yl-2-oxo-ethyl)-carbamic acid tert-butyl ester (0.44 g, 1.8 mmol) in 1,4-dioxane (4.0 mL), HCl (4.0 mL of a 4 M solution in 1,4-dioxane) was added at room temperature. After one h, the precipitated product was collected via filtration and washed with EtOAc. The solid was dried under high vacuum to give 0.23 g (76%) of 2-amino-1-morpholin-4-yl-ethanone hydrochloride which was used without further purification.

後処理

  1. filtrationAfter one h, the precipitated product was collected via filtration
  2. washwashed with EtOAc
  3. customThe solid was dried under high vacuum

出典と根拠

ORDレコード
ord-83fba8d2fdac469082f67417fadf52a3
出典データセット
uspto-grants-2005_04
特許番号
US06878706B1

反応ノート

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