Chlorosuccinimide → 3-Chloro-6-(chloromethyl)pyridazine
反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[Cl:9]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Cl:1][C:2]1[N:3]=[N:4][C:5]([CH2:8][Cl:9])=[CH:6][CH:7]=1参加物
5
実験手順
A suspension of 3-chloro-6-methylpyridazine (3 g), benzoyl peroxide (150 mg) and N-chlorosuccinimide (3.12 g) in CCl4 (30 ml) was refluxed 16 hours, cooled, filtered and evaporated. Chromatography (EtOAc/hexane) gave title compound (1.67 g). NMR δ(CDCl3) 4.87 (2H, s), 7.58 (1H, d), 7.71 (1H, d).
後処理
- temperaturewas refluxed 16 hours
- temperaturecooled
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-9e0c875016194aaabcfe3709d8b2f394
- 出典データセット
- uspto-grants-2005_04
- 特許番号
- US06878704B2
反応ノート
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