Methylamine → 6-AMINO-1-BENZYL-5-METHYLAMINOURACIL

HRID 1814950ノート

反応式

HRID 1814950 の反応式
[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6](=[O:15])[NH:5][C:4](=[O:16])[C:3]=1Br.[CH3:18][NH2:19]>>[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6](=[O:15])[NH:5][C:4](=[O:16])[C:3]=1[NH:19][CH3:18]

参加物

3

反応物 2

HCID 6329MethylamineHCID 8221496-Amino-1-benzyl-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione

生成物 1

HCID 7262256-AMINO-1-BENZYL-5-METHYLAMINOURACIL

反応条件

温度
5 °C

実験手順

6-Amino-1-benzyl-5-bromouracil (134 g) was stirred with 40% aqueous methylamine solution (750 ml) for 24 hours. After cooling to 5° C., the precipitate was filtered and dried under suction to provide 6-amino-1-benzyl-5-methylaminouracil (55 g).

後処理

  1. filtrationthe precipitate was filtered
  2. customdried under suction

出典と根拠

ORDレコード
ord-03cb572469a64cfe963762ddab5d3eb1
出典データセット
uspto-grants-2005_04
特許番号
US06878715B1

反応ノート

読み込み中…