Potassium Carbonate → 4-Methyl-2,3-bis(trifluoromethyl)phenol

HRID 1815516ノート

反応式

HRID 1815516 の反応式
[CH3:1][C:2]12[O:8][CH:5]([CH:6]=[CH:7]1)[C:4]([C:9]([F:12])([F:11])[F:10])=[C:3]2[C:13]([F:16])([F:15])[F:14].C(=O)([O-])[O-].[K+].[K+]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[C:3]=1[C:13]([F:14])([F:15])[F:16]

参加物

3

反応物 2

HCID 11430Potassium CarbonateHCID 132944641-Methyl-2,3-bis(trifluoromethyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene

生成物 1

HCID 108478564-Methyl-2,3-bis(trifluoromethyl)phenol収率 85.2%

実験手順

A mixture of Example 359A (12.0 g, 0.05 mol) and boron trifluoride-diethyl ether complex (150 mL) was stirred at room temperature overnight, then neutralized carefully with 20% aqueous potassium carbonate, then the mixture was extracted with ether. The ether layer was dried over MgSO4 and evaporated under reduced pressure to afford 10.4 g (85%) of the title compound.

後処理

  1. extractionthe mixture was extracted with ether
  2. dry with materialThe ether layer was dried over MgSO4
  3. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-00a43e4494c64760b4d93c96c55c90dc
出典データセット
uspto-grants-2005_04
特許番号
US06878700B1

反応ノート

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