1-Methylcyclopropane-1-sulfonamide → 1-Propylcyclopropane-1-sulfonamide

HRID 1815703ノート

反応式

HRID 1815703 の反応式
C([N:5](CCC)[S:6]([CH:9]1[CH2:11][CH2:10]1)(=[O:8])=[O:7])(C)(C)C.[CH3:15][C:16]1(S(N)(=O)=O)C[CH2:17]1>>[CH2:15]([C:9]1([S:6]([NH2:5])(=[O:7])=[O:8])[CH2:10][CH2:11]1)[CH2:16][CH3:17]

参加物

3

反応物 2

HCID 218898141-Methylcyclopropane-1-sulfonamideHCID 69266674HCID 69266674、化合物

生成物 1

HCID 224993601-Propylcyclopropane-1-sulfonamide収率 80%

実験手順

Step 29b) This compound was made from Compound 29a in 80% yield (25.15 g) from N-tert-butyl-(1-propyl) cyclopropylsulfonamide (42.2 g, 193 mmol) according to the procedure of Steps 3Id (Example 2) described in the synthesis of 1-methylcyclopropylsulfonamide. The compound was recrystallized from EtOAc/hexanes as a white solid: 1H NMR CHLOROFORM-D) δ ppm 0.85 (m, 2H), 0.94 (t, J=7.32 Hz, 3H), 1.36 (m, 2H), 1.47 (m, 2H), 1.87 (m, 2H), 4.42 (s, 2H).

後処理

  1. customThe compound was recrystallized from EtOAc/hexanes as a white solid

出典と根拠

ORDレコード
ord-9fef5e6b0bab4d60a1e597d88cf8eac1
出典データセット
uspto-grants-2005_04
特許番号
US06878722B2

反応ノート

読み込み中…