4-Toluenesulfonyl chloride → 4,7-Bis(p-tolylsulphonyl)-1,4,7-triazacyclononane

関与物質

反応手順

N,N′-bis(p-Toluenesulfonyl)-1,4,7-triazacyclononane (1.1.20) was prepared by reacting (1.1.3) with two equivalents of p-toluenesulfonyl chloride. Two equivalents of N,N′-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane (1.1.20) hydrobromide were reacted with one equivalent of 1,3-diiodopropane in acetonitrile with excess potassium carbonate. 1,3-bis[N,N′-bis(p-Toluenesulfonyl)-1,4,7-triazacyclononane propane (1.1.21) was isolated and purified by chromatography. The p-toluene-sulfonyl groups were removed using sulfuric acid and HBr to yield the title compound (1.1.19). 1.1.22 1,4,7,10-Tetraazabicyclo[5.5.2]tetradecane

情報源と証拠