HCID 22495688、化合物 → HCID 69744908、化合物

HRID 1815856ノート

反応式

HRID 1815856 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[CH:16][C:15]=2[F:23])[CH:10]([CH2:25][CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1CCC(OC(=O)C(C)=O)(C2C3OC=CC=3C=CC=2F)C(CC)C1)C1C=CC=CC=1>>[CH2:1]([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[CH:16][C:15]=2[F:23])[C@H:10]([CH2:25][CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 22495688HCID 22495688、化合物HCID 22495710HCID 22495710、化合物

生成物 1

HCID 69744908HCID 69744908、化合物収率 95.1%

実験手順

Beginning with 5.4 gm (15.3 mMol) 1-benzyl-3-ethyl-4-hydroxy-4-(6-fluorobenzofur-7-yl)piperidine, 5.91 gm (88%) 1-benzyl-3-ethyl-4-(methyl oxoacetoxy)-4-(6-fluorobenzofur-7-yl)piperidine was recovered as an orange oil, essentially as described in EXAMPLE 16. This material was treated with tri(n-butyl)tin hydride essentially as described in EXAMPLE 16 to provide 4.91 gm of the desired compound.

後処理

  1. customwas recovered as an orange oil
  2. additionThis material was treated with tri(n-butyl)tin hydride essentially

出典と根拠

ORDレコード
ord-9bf9289dffec4f1ea2a8aee263834dc3
出典データセット
uspto-grants-2005_04
特許番号
US06881733B1

反応ノート

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