Ethanethiol → Ethyl (S)-4-(hydroxyphenyl)-3-(pyridin-3-yl)butanoate

HRID 1816012ノート

反応式

HRID 1816012 の反応式
CO[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C@H:10]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:5][CH:4]=1.C(S)C.[Al+3].[Cl-].[Cl-].[Cl-].C([O-])(O)=[O:31].[Na+]>C(Cl)Cl>[OH:31][C:7]1[CH:8]=[CH:3][CH:4]=[CH:5][C:6]=1[CH2:9][C@H:10]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]

参加物

6

反応物 4

HCID 6343EthanethiolHCID 516892Sodium BicarbonateHCID 6451240Aluminum(III) ChlorideHCID 59997619Ethyl (S)-4-(4-methoxyphenyl)-3-(pyridin-3-yl)butanoate

生成物 1

HCID 86759664Ethyl (S)-4-(hydroxyphenyl)-3-(pyridin-3-yl)butanoate収率 73%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of ethyl (S)-4-(4-methoxyphenyl)-3-(pyridin-3-yl)butanoate (9.25 g, 31 mmole) in CH2Cl2 (150 mL) was cooled to 0° C. Ethanethiol (11.5 mL, 155 mmole) was added, then AlCl3 (20.7 g, 155 mmole) was added portionwise. After 2 hr, the mixture was poured over ice, allowed to warm to RT, and neutralized with NaHCO3. The resulting suspension was filtered through celite® and the filter pad was washed with CH2Cl2. The layers were separated and the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried (MgSO4) and concentrated. Flash chromatography on silica gel (1:1 EtOAc/hexanes) afforded the title compound (6.435 g, 73%) 1H NMR (400 MHz, CDCl3) δ 8.72, 8.41 (dd, J=4.9, 1.5 Hz, 1 H), 8.24 (narrow m, 1 H), 7.26 (dd, J=7.8, 4.9 Hz, 1 H). 6.78 (d, J=8.5 Hz, 2 H), 6.64 (d, J=8.5 Hz, 2 H), 4.03 (q, J=7.1 Hz, 2 H), 3.34-3.48 (m, 1 H), 2.92 (dd, J=13.7, 6.1 Hz, 1 H). 2.69-2.81 (m, 2 H), 2.64 (dd, J=15.6, 8.7 Hz, 1 H), 1.13 (t, J=7.1 Hz, 3 H); MS (ES) m/e 286 (M+H)+.

後処理

  1. additionthe mixture was poured over ice
  2. filtrationThe resulting suspension was filtered through celite®
  3. washthe filter pad was washed with CH2Cl2
  4. customThe layers were separated
  5. extractionthe aqueous layer was extracted with CH2Cl2
  6. dry with materialThe combined organic layers were dried (MgSO4)
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-5207fca5c0d4499691b04b2ea3f207af
出典データセット
uspto-grants-2005_04
特許番号
US06881736B1

反応ノート

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