Cyclopropylamine → HCID 22493363、化合物

反応式

[NH2:1][C:2]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:3]=1[C:4]([NH:6][CH:7]1[CH2:9][CH2:8]1)=[O:5].[CH:15]1([NH2:18])[CH2:17]C1.FC1C=[CH:22][C:23]2[NH:28]C(=O)OC(=O)C=2C=1>>[CH:7]1([NH:6][C:4](=[O:5])[C:3]2[CH:10]=[C:11]([F:14])[CH:12]=[CH:13][C:2]=2[NH:1][CH2:17][C:15]2[NH:18][CH2:22][CH2:23][N:28]=2)[CH2:9][CH2:8]1

参加物

反応物 3

HCID 69828Cyclopropylamine

HCID 2885605-Fluoroisatoic anhydride

HCID 22493342HCID 22493342、化合物

生成物 1

HCID 22493363HCID 22493363、化合物

実験手順

2-Amino-N-cyclopropyl-5-fluorobenzamide (prepared from cyclopropylamine and 6-fluoro-2H-3,1-benzoxazine-2,4(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give N-cyclopropyl-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]-5-fluorobenzamide.