2-Nitrobenzamide → N-[(dimethylamino)ethylidene]-2-nitrobenzamide

HRID 1816299ノート

反応式

HRID 1816299 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7])([O-:3])=[O:2].CO[C:15](OC)([N:17]([CH3:19])[CH3:18])[CH3:16]>>[CH3:18][N:17]([CH2:15][CH:16]=[N:8][C:6](=[O:7])[C:5]1[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=1[N+:1]([O-:3])=[O:2])[CH3:19]

参加物

3

反応物 2

HCID 118762-NitrobenzamideHCID 878351,1-Dimethoxyethyl(dimethyl)amine

生成物 1

HCID 57019786N-[(dimethylamino)ethylidene]-2-nitrobenzamide

反応条件

温度
120 °C

実験手順

2-Nitrobenzamide (12.4 g, 75 mmol) was dissolved to dimethylacetamide-dimethylacetal (25 mL ) and heated to 120° C. for 2 hours. Upon cooling, the reaction was passed through a short silica column, eluting with ethyl acetate. The crystals that formed in the collected eluent were collected by filtration and rinsed with diethyl ether to provide N-[(dimethylamino)ethylidene]-2-nitrobenzamide (7.73 g).

後処理

  1. temperatureUpon cooling
  2. washeluting with ethyl acetate
  3. customThe crystals that formed in the collected eluent
  4. filtrationwere collected by filtration
  5. washrinsed with diethyl ether

出典と根拠

ORDレコード
ord-aa53b9ca7e0b408fa77a16147ab5a853
出典データセット
uspto-grants-2005_04
特許番号
US06884801B1

反応ノート

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