Sodium sulfide nonahydrate → 2-(3-Methyl-1,2,4-oxadiazol-5-yl)aniline

HRID 1816301ノート

反応式

HRID 1816301 の反応式
[CH3:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N+:13]([O-])=O)[O:4][N:3]=1.O.O.O.O.O.O.O.O.O.[S-2].[Na+].[Na+]>O1CCOCC1.O>[CH3:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[NH2:13])[O:4][N:3]=1

参加物

5

反応物 2

HCID 73972Sodium sulfide nonahydrateHCID 126766793-Methyl-5-(2-nitrophenyl)-1,2,4-oxadiazole

生成物 1

HCID 126766822-(3-Methyl-1,2,4-oxadiazol-5-yl)aniline収率 62.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

3-methyl-5-(2-nitrophenyl)-1,2,4-oxadiazole (1.0 g, 4.8 mmol) in dioxane (11 mL) at 80°0 C. was treated with 11 mL of an aqueous solution of sodium sulfide nonahydrate (2.55 g, 10.6 mmol), also at 80° C. After stirring at that temperature for 45 minutes, the reaction was diluted with water (15 mL) and cooled in an ice bath. The resulting precipitate was collected by filtration and rinsed with water to afford 3-methyl-5-(2-aminophenyl)-1,2,4-oxadiazole (522 mg).

後処理

  1. temperaturecooled in an ice bath
  2. filtrationThe resulting precipitate was collected by filtration
  3. washrinsed with water

出典と根拠

ORDレコード
ord-5a38ef6cc2cd48e09ea0cb14ec319729
出典データセット
uspto-grants-2005_04
特許番号
US06884801B1

反応ノート

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