Methyl 2-(bromomethyl)-6-methylbenzoate → Rac-cis-2-[3-[2-(4-fluorophenyl)oxazol-4-ylmethoxy]cyclohexylmethoxymethyl]-6-methylbenzoic acid
反応式
[OH:1][CH2:2][C@@H:3]1[CH2:8][CH2:7][CH2:6][C@H:5]([OH:9])[CH2:4]1.Br[CH2:11][C:12]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:13]=1[C:14]([O:16]C)=[O:15].[F:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[O:31][CH:32]=[C:33]([CH2:35]I)[N:34]=2)=[CH:26][CH:25]=1>>[F:23][C:24]1[CH:25]=[CH:26][C:27]([C:30]2[O:31][CH:32]=[C:33]([CH2:35][O:9][C@@H:5]3[CH2:6][CH2:7][CH2:8][C@H:3]([CH2:2][O:1][CH2:11][C:12]4[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:13]=4[C:14]([OH:16])=[O:15])[CH2:4]3)[N:34]=2)=[CH:28][CH:29]=1参加物
4
実験手順
Reacting cis-3-hydroxymethylcyclohexanol, bromide 4 and iodide 2 in a reverse order relative to Example XXIV gave the product 41 of molecular weight 453.52 (C26H28FNO5); MS(ESI): 454 (M+H+).