Water → 3-(Azidomethyl)-2-methoxypyridine

HRID 1816606ノート

反応式

HRID 1816606 の反応式
[CH3:1][O:2][C:3]1[C:8]([CH2:9]O)=[CH:7][CH:6]=[CH:5][N:4]=1.C1(P([N:25]=[N+:26]=[N-:27])(C2C=CC=CC=2)=O)C=CC=CC=1.C12CCCCC1CCCNN=2.O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:25]=[N+:26]=[N-:27])=[CH:7][CH:6]=[CH:5][N:4]=1

参加物

6

反応物 4

HCID 962WaterHCID 199401P,P-Diphenylphosphinic azideHCID 10630565(2-Methoxypyridin-3-yl)methanolHCID 66879275Diazabicyclo[5.4.0]undecene

生成物 1

HCID 224939123-(Azidomethyl)-2-methoxypyridine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

7.4 g of 2-methoxy-3-hydroxymethylpyridine was dissolved in 100 ml toluene, and 13.8 ml diphenyl phosphoryl azide and 9.5 ml diazabicyclo[5.4.0]undecene were added, and the mixture was stirred overnight at room temperature. Water was added to the reaction product which was then extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 9.5 g of [(2-methoxy-3-pyridyl)methyl]azide.

後処理

  1. extractionwas then extracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-ce86c1b95beb4a3ebd84d1468b145ddc
出典データセット
uspto-grants-2005_04
特許番号
US06884821B1

反応ノート

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