Water → HCID 22494742、化合物

反応式

CS(O[CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)(=O)=O.[C:21]([O-:24])(=[S:23])[CH3:22].[K+].O>CS(C)=O>[C:21]([S:23][CH:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:13]=[CH:14][C:15]([N+:18]([O-:20])=[O:19])=[CH:16][CH:17]=2)[CH2:10][CH2:11]1)(=[O:24])[CH3:22]

参加物

実験手順

A solution of 4-[4-(methanesulfonyloxy)piperidin-1-yl]nitrobenzene (2.0 g), and potassium thioacetate (1.14 g) in dimethylsulfoxide (DMSO) (20 ml) was stirred at 100-110° C. for 3 hours. The reaction mixture was poured into water (100 ml) and extracted twice with ethyl acetate (100 ml). The extracts were collected, washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and evaporated in vacuo. The resulting precipitates were washed with IPE (50 ml), collected by filtration and dried in vacuo to give 4-(4-acetylthiopiperidin-1-yl)nitrobenzene (1.15 g).