4-Bromophenol → 1-Bromo-4-(4-bromobutoxy)benzene

HRID 1816769ノート

反応式

HRID 1816769 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[Br:9][CH2:10][CH2:11][CH2:12][CH2:13]Br.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.C(OCC)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:13][CH2:12][CH2:11][CH2:10][Br:9])=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 78084-BromophenolHCID 80561,4-DibromobutaneHCID 11430Potassium Carbonate

生成物 1

HCID 80633591-Bromo-4-(4-bromobutoxy)benzene

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 4-bromophenol (3 g) and 1,4-dibromobutane (6.2 ml) in N,N-dimethylformamide (30 ml) was treated with potassium carbonate (2.89 g) at room temperature for 27 hours. The mixture was diluted with ethyl acetate and washed with brine. The organic layer was dried over magnesium sulfate, filtered, and evaporated. The residue was purified by silica gel chromatography (25:1 hexane-ethyl acetate elution) to give 1-bromo-4-(4-bromobutoxy)benzene (3.09 g).

後処理

  1. washwashed with brine
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. filtrationfiltered
  4. customevaporated
  5. customThe residue was purified by silica gel chromatography (25:1 hexane-ethyl acetate elution)

出典と根拠

ORDレコード
ord-f9fe90f1826b433a9035dd98e41faffc
出典データセット
uspto-grants-2005_04
特許番号
US06884868B1

反応ノート

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