Water → 1-Bromo-4-(4-methoxybutoxy)benzene

HRID 1816770ノート

反応式

HRID 1816770 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH2:11][CH2:12]Br)=[CH:4][CH:3]=1.C[O-].[Na+].O.[C:18](OCC)(=[O:20])C>CO>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][O:20][CH3:18])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 80633591-Bromo-4-(4-bromobutoxy)benzeneHCID 10942334Sodium Methoxide

生成物 1

HCID 224947841-Bromo-4-(4-methoxybutoxy)benzene

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

A solution of 1-bromo-4-(4-bromobutoxy)benzene (3.05 g) in methanol (30 ml) was treated with 28% sodium methoxide in methanol (2.43 ml), and the solution was refluxed for 5 hours. After cooling, the reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was washed with brine. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (10:1 hexane-ethyl acetate elution) to give 1-bromo-4-(4-methoxybutoxy)benzene (1.95 g).

後処理

  1. temperaturethe solution was refluxed for 5 hours
  2. temperatureAfter cooling
  3. washThe organic layer was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationThe magnesium sulfate was filtered off
  6. concentrationthe filtrate was concentrated under reduced pressure
  7. customThe residue was purified by silica gel chromatography (10:1 hexane-ethyl acetate elution)

出典と根拠

ORDレコード
ord-ae6c01ae7a1746f598f9c460ab58f3f5
出典データセット
uspto-grants-2005_04
特許番号
US06884868B1

反応ノート

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