Diethyl Ether → Ethyl 6-oxohexanoate
反応式
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[CH2:12]([O:14][C:15](=[O:22])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][OH:21])[CH3:13].CCOCC>ClCCl>[CH2:12]([O:14][C:15](=[O:22])[CH2:16][CH2:17][CH2:18][CH2:19][CH:20]=[O:21])[CH3:13]参加物
5
実験手順
To a solution of pyridinium chlorochromate (2.0 g) in dichloromethane (15 ml) was added a solution of 6-hydroxyhexanoic acid ethyl ester (1.0 g) in dichloromethane (1.5 ml) in one portion and stirred for 1.5 hours at ambient temperature. Ether (15 ml) was added to the reaction mixture, and the insoluble material removed by filtration and discarded. The filtrate was purified by silica gel chromatography (diethyl ether) to give 6-oxohexanoic acid ethyl ester (884.6 mg), as a pale green oil.
後処理
- customthe insoluble material removed by filtration
- customThe filtrate was purified by silica gel chromatography (diethyl ether)
出典と根拠
- ORDレコード
- ord-2e124303135d48458d0b1bba485cebe5
- 出典データセット
- uspto-grants-2005_04
- 特許番号
- US06884868B1
反応ノート
読み込み中…