4-Bromofuran-2-carbonitrile → 4-(5-Methyl-2-oxo-5-thien-2-yl-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl)-2-furonitrile

HRID 1816917

反応式

HRID 1816917 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][O:8][C:7]([CH3:18])([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)[C:6]=2[CH:19]=1.Br[C:21]1[CH:22]=[C:23]([C:26]#[N:27])[O:24][CH:25]=1>>[CH3:18][C:7]1([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)[C:6]2[CH:19]=[C:2]([C:21]3[CH:22]=[C:23]([C:26]#[N:27])[O:24][CH:25]=3)[CH:3]=[CH:4][C:5]=2[NH:11][C:10](=[O:12])[CH2:9][O:8]1

参加物

3

反応物 2

HCID 219862204-Bromofuran-2-carbonitrileHCID 688661097-Bromo-5-methyl-5-thien-2-yl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one

生成物 1

HCID 113486714-(5-Methyl-2-oxo-5-thien-2-yl-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl)-2-furonitrile

実験手順

Prepared from 7-bromo-5-methyl-5-thien-2-yl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one and 4-bromofuran-2-carbonitrile generally according to the coupling procedure described in examples 82 and 1. 1H-NMR (DMSO-d6) δ 10.09 (s, 1H), 8.60 (s, 1H), 8.16 (s, 1H), 7.61 (m, 2H), 7.54 (dd, J=4.9, 1.0 Hz, 1H), 7.22 (d, J=8.3 Hz, 1H), 6.97 (dd, J=5.4, 3.9 Hz, 1H), 6.84 (dd, J=3.4, 1.0 Hz, 1H), 4.16 (d, J=15.6 Hz, 1H), 4.00 (d, J=15.6 Hz, 1H), 2.07 (s, 3H); MS (ES) m/z 351 (M+H)+.

出典と根拠

ORDレコード
ord-23e6e1526a51484696bb27617fa0eeef
出典データセット
uspto-grants-2009_10
特許番号
US07598237B2

関連ノート

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