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Sodium hydride → 2-chloro-7-(2-fluorobenzyl)-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | alpha-Bromo-o-fluorotoluene | HCID 67968 | — |
| 反応物 | HCID 178418860 | HCID 178418860 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-chloro-7-(2-fluorobenzyl)-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine | HCID 21976427 | 76.3% |
反応手順
A solution of 2-chloro4(2-furyl)-1H-pyrrolo[2,3-d]pyrimidine (219 mg, 1 mmol) in DMF (2 mL) at 0° C. was treated with NaH (40 mg, 60%, 1 inmol), stirred for 20 min, treated with 2-fluorobenzyl bromide (120 μL, 1 mmol), stirred at room temperature for 1 h, quenched with water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo and purified by chromatography (EtOAc:Heptane, 1:4) to give the title compound (250 mg, 76%) as a cream solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07598256B2 |
| 出典データセット | uspto-grants-2009_10 |
| ORD ID | ord-4035ab3283754a3fbfd54936822a479b |
| 出典メモ | uspto-grants-2009_10 |