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Trifluoroacetic acid → 1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Trifluoroacetate | HCID 84468 | — |
| 反応物 | 4-(1-Benzyl-2-carbamoyl-6-fluoro-1H-indol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester | HCID 68586044 | — |
| 生成物 | 1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide | HCID 24953072 | — |
反応手順
1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide was prepared as trifluoroacetate salt by hydrogenation of 4-(1-Benzyl-2-carbamoyl-6-fluoro-1H-indol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester, followed by deprotection with trifluoroacetic acid, using the procedure of steps 3 and 4 of Example 2. MS: (M+H)+ 352.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741326B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-b950e1b62e0048149a0aa87dc89f4bd1 |
| 出典メモ | uspto-grants-2010_06 |