Diethylamine → 6-[(3-chloro-4-fluoro-phenyl)methyl]-N,N-diethyl-4-hydroxy-2-methyl-3,5-dioxo-7,8-dihydro-2,6-naphthyridine-1-carboxamide

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[F:28])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([O:22]C)[C:10](=[O:21])[N:11]([CH3:20])[C:12]=2[C:16]([O:18]C)=O)[C:7]1=[O:24].[CH2:29]([NH:31][CH2:32][CH3:33])[CH3:30]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[F:28])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:22])[C:10](=[O:21])[N:11]([CH3:20])[C:12]=2[C:16]([N:31]([CH2:32][CH3:33])[CH2:29][CH3:30])=[O:18])[C:7]1=[O:24]

参加物

反応物 2

HCID 8021Diethylamine

HCID 69058384Methyl 6-(3-chloro-4-fluorobenzyl)-4-methoxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

生成物 1

HCID 546818736-[(3-chloro-4-fluoro-phenyl)methyl]-N,N-diethyl-4-hydroxy-2-methyl-3,5-dioxo-7,8-dihydro-2,6-naphthyridine-1-carboxamide

実験手順

The title compound was prepared from methyl 6-(3-chloro-4-fluorobenzyl)-4-methoxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate in a manner similar to that described in Example 12, Steps 12, 13 and 14, using diethyl amine in place of dimethylamine in the step corresponding to Step 13 of Example 12.

出典と根拠

ORDレコード: ord-7c90e7c47941423ba112e40a61765455
出典データセット: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07598264B2

反応ノート

読み込み中…