Piperidine → 7,7-Dimethyl-5-oxo-2-piperidin-1-yl-5,6,7,8-tetrahydro-quinoline-3-carbonitrile

HRID 1817816ノート

反応式

HRID 1817816 の反応式
[CH3:1][C:2]1([CH3:17])[CH2:11][C:10]2[N:9]=[C:8](SC)[C:7]([C:14]#[N:15])=[CH:6][C:5]=2[C:4](=[O:16])[CH2:3]1.[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>C(O)C>[CH3:1][C:2]1([CH3:17])[CH2:11][C:10]2[N:9]=[C:8]([N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:7]([C:14]#[N:15])=[CH:6][C:5]=2[C:4](=[O:16])[CH2:3]1

参加物

4

反応物 2

HCID 8082PiperidineHCID 31375507,7-Dimethyl-2-methylsulfanyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carbonitrile

生成物 1

HCID 578831717,7-Dimethyl-5-oxo-2-piperidin-1-yl-5,6,7,8-tetrahydro-quinoline-3-carbonitrile収率 28.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 7,7-dimethyl-2-methylsulfanyl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carbonitrile (0.25 g, 1 mmol) and piperidine (0.32 ml, 4 mmol) in dry ethanol (3 ml) was stirred at reflux for 36 h. The reaction mixture was then evaporated under reduced pressure. The residue was purified by flash chromatography on silica gel (chloroform-methanol, 50:1) to give the title compound (0.08 g, 28%) as a colorless solid.

後処理

  1. temperatureat reflux for 36 h
  2. customThe reaction mixture was then evaporated under reduced pressure
  3. customThe residue was purified by flash chromatography on silica gel (chloroform-methanol, 50:1)

出典と根拠

ORDレコード
ord-61ad601957ff441aa8913a521fedbe52
出典データセット
uspto-grants-2009_10
特許番号
US07598384B2

反応ノート

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