Nitric Acid → 5-Bromo-3-nitro-2-pyridone

HRID 1817906

反応式

HRID 1817906 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[N+:9]([O-])([OH:11])=[O:10]>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5](=[O:8])[NH:6][CH:7]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 5995285-Bromo-2-hydroxypyridine

生成物 1

HCID 851475-Bromo-3-nitro-2-pyridone収率 68%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

To a solution of 5-bromopyridin-2(1H)-one (Aldrich, 3.0 g, 17.2 mmol) in sulfuric acid (18 mL) was added nitric acid (60-61%, Wako Pure Chemical Industries, Ltd., 6 mL) at 0° C. The mixture was allowed to warm to room temperature and stirred for 3 h. The mixture was poured into ice water and obtained precipitate was collected by filtration. The solid was washed with water and dried in vacuo to afford the title compound (2.5 g, 68%) as a yellow solid.

後処理

  1. customobtained precipitate
  2. filtrationwas collected by filtration
  3. washThe solid was washed with water
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-5f67e26f086f409cb172e3afd6e785a8
出典データセット
uspto-grants-2009_10
特許番号
US07598393B2

関連ノート

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