Hydrochloric Acid → (E,E)-2-(3,4-Dimethoxybenzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile

HRID 1818044

反応式

HRID 1818044 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[OH:12])[CH:5]=[CH:6][CH:7]=O.[C:13]([CH2:15][C:16]([N-:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[CH:21]=1)=[O:17])#[N:14].N1CCCCC1.Cl>C(O)C.O>[CH3:29][O:28][C:22]1[CH:21]=[C:20]([CH:25]=[CH:24][C:23]=1[O:26][CH3:27])[CH2:19][NH:18][C:16](/[C:15](=[CH:7]/[CH:6]=[CH:5]/[C:4]1[CH:9]=[CH:10][C:11]([OH:12])=[C:2]([OH:1])[CH:3]=1)/[C:13]#[N:14])=[O:17]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 8082PiperidineHCID 4430343-(3,4-Dihydroxy-phenyl)-2-propenalHCID 178491200HCID 178491200、化合物

生成物 1

HCID 11588987(E,E)-2-(3,4-Dimethoxybenzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile収率 68.4%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To 3,4-dihydroxycinnamaldehyde (32 mg, 0.2 mmol) and N-(cyanoacetyl)3,4-dimethoxybenzylamide (47 mg, 0.2 mmol) in 8 mL of ethanol 40 μl of piperidine was added and the mixture was kept at room temperature for 1 h. 2N HCl and water were added and the precipitated solid was recrystallized from ethanol-water to give 52 mg (68%) of an orange solid. The product gave the following analytical data:

後処理

  1. customthe precipitated solid was recrystallized from ethanol-water

出典と根拠

ORDレコード
ord-91d97045d81d41adbde9f61c4ab6b42e
出典データセット
uspto-grants-2009_10
特許番号
US07598419B2

関連ノート

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