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Piperidine → (E,E)-2-(3-Fluorobenzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3-(3,4-Dihydroxy-phenyl)-2-propenal | HCID 443034 | — |
| 反応物 | 2-cyano-N-[(3-fluorophenyl)methyl]acetamide | HCID 28970880 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (E,E)-2-(3-Fluorobenzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acrylonitrile | HCID 11500983 | — |
反応手順
The compound was prepared as described in Example 37 by adding piperidine to a solution of 3,4-dihydroxycinnamaldehyde (35 mg, 0.2 mmol) and 2-cyano-N-(3-fluorobenzyl)acetamide (38 mg, 0.2 mmol) in ethanol. After recrystallization from ethanol-water a yellow solid was obtained (51 mg, 75%). The product gave the following analytical data:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07598419B2 |
| 出典データセット | uspto-grants-2009_10 |
| ORD ID | ord-8b4890e42bc4430b84d5f68d83900e42 |
| 出典メモ | uspto-grants-2009_10 |