Hydrochloric Acid → N-(4-aminobutyl)methanesulfonamide hydrochloride

HRID 1818154

反応式

HRID 1818154 の反応式
[ClH:1].[CH3:2][S:3]([NH:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)(=[O:5])=[O:4]>C(O)C>[ClH:1].[NH2:11][CH2:10][CH2:9][CH2:8][CH2:7][NH:6][S:3]([CH3:2])(=[O:5])=[O:4]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 54180899Tert-butyl[4-(methanesulfonylamino)butyl]carbamate

生成物 1

HCID 21984197N-(4-aminobutyl)methanesulfonamide hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
100 °C

実験手順

A solution of hydrochloric acid in ethanol was added to a solution of tert-butyl [4-(methanesulfonylamino)butyl]carbamate (18.9 g, 71.1 mmol) in ethanol (100 mL), and the reaction was heated at 100° C. for two hours. The solvent was removed under reduced pressure. A mixture of dichloromethane:hexanes was added to the resulting oil and removed under reduced pressure; this process was repeated several times. The residue was dried for three days under vacuum to provide 14.3 g of N-(4-aminobutyl)methanesulfonamide hydrochloride as a tan solid.

後処理

  1. customThe solvent was removed under reduced pressure
  2. additionA mixture of dichloromethane
  3. additionhexanes was added to the resulting oil
  4. customremoved under reduced pressure
  5. customThe residue was dried for three days under vacuum

出典と根拠

ORDレコード
ord-3bb46c721162469793e511e2b3d74606
出典データセット
uspto-grants-2009_10
特許番号
US07598382B2

関連ノート

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