1-(4-((4-(Bromomethyl)benzyl)oxy)-3-chloro-2-hydroxyphenyl)ethanone → 1-(4-{4-[3-(2-Amino-pyrimidin-4-yl)-benzyl]-benzyloxy}-3-chloro-2-hydroxy-phenyl)-ethanone

HRID 1818532

反応式

HRID 1818532 の反応式
CC1(C)COB([C:8]2[CH:9]=[C:10]([C:14]3[CH:19]=[CH:18][N:17]=[C:16]([NH2:20])[N:15]=3)[CH:11]=[CH:12][CH:13]=2)OC1.Br[CH2:23][C:24]1[CH:42]=[CH:41][C:27]([CH2:28][O:29][C:30]2[CH:35]=[CH:34][C:33]([C:36](=[O:38])[CH3:37])=[C:32]([OH:39])[C:31]=2[Cl:40])=[CH:26][CH:25]=1>>[NH2:20][C:16]1[N:15]=[C:14]([C:10]2[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=2)[CH2:23][C:24]2[CH:25]=[CH:26][C:27]([CH2:28][O:29][C:30]3[CH:35]=[CH:34][C:33]([C:36](=[O:38])[CH3:37])=[C:32]([OH:39])[C:31]=3[Cl:40])=[CH:41][CH:42]=2)[CH:19]=[CH:18][N:17]=1

参加物

3

反応物 2

HCID 574384161-(4-((4-(Bromomethyl)benzyl)oxy)-3-chloro-2-hydroxyphenyl)ethanoneHCID 666995914-[3-(5,5-Dimethyl-[1,3,2]dioxaborinan-2-yl)-phenyl]-pyrimidin-2-ylamine

生成物 1

HCID 578844811-(4-{4-[3-(2-Amino-pyrimidin-4-yl)-benzyl]-benzyloxy}-3-chloro-2-hydroxy-phenyl)-ethanone

実験手順

The title compound is prepared essentially as described in Example 92 using 4-[3-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-phenyl]-pyrimidin-2-ylamine (327 mg, 1.15 mmol) and 1-[4-(4-bromomethyl-benzyloxy)-3-chloro-2-hydroxy-phenyl]-ethanone (400 mg, 1.08 mmol). The title compound is isolated (109 mg, 0.237 mmol) as a yellow solid: 1H NMR (DMSO-d6) δ 2.10 (s, 3H), 4.04 (s, 2H), 5.30 (s, 2H), 6.62 (m, 2H), 6.88 (d, 1H), 7.08 (m, 1H), 7.29 (m, 2H), 7.40 (m, 4H), 7.92 (m, 3H), 8.28 (d, 1H), 13.12 (s, 1H); MS (m/z): 458.2 (M−1).

後処理

  1. customThe title compound is prepared essentially

出典と根拠

ORDレコード
ord-6202528fe8a142718b3dff73aa92d1a5
出典データセット
uspto-grants-2009_10
特許番号
US07598423B2

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