1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → 1-[5-fluoro-3-(3-fluoro-benzyl)-7-(1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone

関与物質

反応手順

1-[5-Fluoro-3-(3-fluoro-benzyl)-7-(1-triisopropylsilanyl-1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone (0.38 gm, 0.748 mmol) and tetrabutylammonium fluoride hydrate (0.28 gm, 0.89 mmol) were added to tetrahydrofuran (10 ml) and stirred at room temperature for four hours. The solution was concentrated under reduced pressure and purified by column chromatography to give 1-[5-fluoro-3-(3-fluoro-benzyl)-7-(1H-pyrrol-3-yl)-benzofuran-2-yl]-ethanone (0.205 gm, 79% yield).

情報源と証拠