Bromine → 5-Bromo-3-fluoro-2-hydroxybenzoic acid

HRID 1820107ノート

反応式

HRID 1820107 の反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=[O:6])[C:3]=1[OH:11].[Br:12]Br>C(O)(=O)C.O>[Br:12][C:9]1[CH:10]=[C:2]([F:1])[C:3]([OH:11])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6]

参加物

5

反応物 2

HCID 24408BromineHCID 2687243-Fluoro-2-hydroxybenzoic acid

生成物 1

HCID 117704165-Bromo-3-fluoro-2-hydroxybenzoic acid

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

5.00 g (32 mmol) of 3-fluorosalicylic acid was suspended in 50 ml of glacial acetic acid. 2.2 ml of bromine were added and the mixture was stirred at ambient temperature for 48 h. The resulting suspension was diluted with 500 ml of water and the precipitate filtered off and dried by suction to afford 9.394 g of 5-bromo-3-fluoro-2-hydroxybenzoic acid as an ivory solid.

後処理

  1. filtrationthe precipitate filtered off
  2. customdried by suction

出典と根拠

ORDレコード
ord-fd0a2b3d96e24367b50df51d1714bec7
出典データセット
uspto-grants-2009_10
特許番号
US07601839B2

反応ノート

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