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4-(4-Chlorophenyl)-4-hydroxypiperidine → N-(1-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-4-(methylthio)-1-oxobutan-2-yl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(4-Chlorophenyl)-4-hydroxypiperidine | HCID 38282 | — |
| 反応物 | 3-Methyl-2-(phenylformamido)butanoic acid | HCID 226682 | — |
| 反応物 | Benzoyl-dl-methionine | HCID 295480 | — |
| 反応物 | 4-(4-chlorophenyl)piperidine Hydrochloride | HCID 2757843 | — |
| 生成物 | N-(1-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-4-(methylthio)-1-oxobutan-2-yl)benzamide | HCID 57889006 | — |
反応手順
Example 217 was prepared in a similar manner as described for the preparation of Example 208 with the exceptions that benzoyl-DL-methionine and 4-(4-chlorophenyl)-4-hydroxypiperidine were substituted for benzoyl-DL-valine and 4-(4-chlorophenyl)piperidine hydrochloride, respectively. MS found: (M+H)+=448.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07601844B2 |
| 出典データセット | uspto-grants-2009_10 |
| ORD ID | ord-54dde8d92b244532a474e24aaaae48ed |
| 出典メモ | uspto-grants-2009_10 |