Ethanol → HCID 23109914、化合物
反応式
[ClH:1].C(OCC)(=O)C.[N:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]([CH2:47][C:48]2[CH:53]=[CH:52][N:51]=[CH:50][CH:49]=2)[CH2:16][CH2:17][C:18]2([CH2:24][CH2:25][N:26]3[CH2:31][CH2:30][CH:29]([N:32]([C:40]4[CH:45]=[CH:44][C:43]([CH3:46])=[CH:42][CH:41]=4)[C:33]([C:35]4[O:36][CH:37]=[CH:38][CH:39]=4)=[O:34])[CH2:28][CH2:27]3)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:10][CH:9]=1.C(O)C>C(OCC)(=O)C>[ClH:1].[ClH:1].[ClH:1].[ClH:1].[N:51]1[CH:52]=[CH:53][C:48]([CH2:47][N:15]([CH2:14][C:11]2[CH:10]=[CH:9][N:8]=[CH:13][CH:12]=2)[CH2:16][CH2:17][C:18]2([CH2:24][CH2:25][N:26]3[CH2:31][CH2:30][CH:29]([N:32]([C:40]4[CH:41]=[CH:42][C:43]([CH3:46])=[CH:44][CH:45]=4)[C:33]([C:35]4[O:36][CH:37]=[CH:38][CH:39]=4)=[O:34])[CH2:28][CH2:27]3)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:49][CH:50]=1参加物
5
実験手順
After adding a 4N hydrochloric acid/ethyl acetate solution (0.35 mL, 1.4 mmol) to a solution of N-[1-[2-[1-[2-[bis(pyridin-4-ylmethyl)amino]ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide (171 mg, 0.28 mmol) in ethyl acetate (2 mL)-ethanol (2 mL), the mixture was stirred at room temperature for 10 minutes. Ethyl acetate (3 mL) was added to the reaction mixture, and after stirring for 20 minutes in an ice bath, the precipitated crystals were filtered out and dried under reduced pressure to obtain the title compound as a white solid (136 mg, 0.18 mmol) (64% yield).