Sodium Methoxide → HCID 69038439、化合物

HRID 1820759ノート

反応式

HRID 1820759 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[C:18](Cl)[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:21][O-:22].[Na+]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[C:18]([O:22][CH3:21])[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 10942334Sodium MethoxideHCID 86600711845617-09-6

生成物 1

HCID 69038439HCID 69038439、化合物

実験手順

1 mmol of 4-(4-Chloro-[1,3,5]triazin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester [example 4.11(a)] was dissolved in a solution of sodium methanolate (prepared by dissolving 1 mmol of sodium in 5 ml of methanol). The mixture was stirred at room temperature for 1 hour, concentrated and the title compound purified by recrystallisation from ethyl acetate/cyclohexane. MS (m/e): 296.3 (MH+, 100%)

後処理

  1. concentrationconcentrated
  2. customthe title compound purified by recrystallisation from ethyl acetate/cyclohexane

出典と根拠

ORDレコード
ord-036b2c51955d4b00a5d8c7ebe73a6361
出典データセット
uspto-grants-2009_10
特許番号
US07605163B2

反応ノート

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