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3,4-Dimethoxyphenylboronic acid → 8-[5-Chloro-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-Dimethoxyphenylboronic acid | HCID 2734702 | — |
| 反応物 | 3-Bromo-(1-phenylsulfonyl)indole | HCID 2776215 | — |
| 反応物 | 3-methylquinoline-8-sulfonyl Chloride | HCID 3574807 | — |
| 反応物 | 3-(Cyclopentyloxy)-4-methoxybenzeneboronic acid | HCID 4197993 | — |
| 反応物 | 1-Benzenesulfonyl-3-bromo-5-chloro-indole | HCID 69006690 | — |
| 生成物 | 8-[5-Chloro-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline | HCID 57891745 | — |
反応手順
8-[5-Chloro-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline 95 was prepared using the same protocol as described in Examples 21 and 22, substituting 8-quinoline-sulfonyl chloride, 1-Benzenesulfonyl-3-bromoindole and 3,4-dimethoxyphenyl boronic acid with 3-methyl-quinoline-8-sulfonyl chloride, 1-Benzenesulfonyl-3-bromo-5-chloro-indole and 3-cyclopentyloxy-4-methoxy-phenylboronic acid respectively. MS(ESI) [M+H+]+=547.10.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07605168B2 |
| 出典データセット | uspto-grants-2009_10 |
| ORD ID | ord-40cee7d49bd44894b607fadfab00dc04 |
| 出典メモ | uspto-grants-2009_10 |