Benzyl Bromide → 7,8-Dihydro-2-(phenylmethoxy)-5(6H)-quinolinone

HRID 1821093ノート

反応式

HRID 1821093 の反応式
[NH:1]1[C:10]2[CH2:9][CH2:8][CH2:7][C:6](=[O:11])[C:5]=2[CH:4]=[CH:3][C:2]1=[O:12].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[CH2:13]([O:12][C:2]1[CH:3]=[CH:4][C:5]2[C:6](=[O:11])[CH2:7][CH2:8][CH2:9][C:10]=2[N:1]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 7498Benzyl BromideHCID 2674502-Hydroxy-7,8-dihydro-5(6H)-quinolinone

生成物 1

HCID 104449777,8-Dihydro-2-(phenylmethoxy)-5(6H)-quinolinone収率 92%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 7,8-dihydro-1H,6H-quinoline-2,5-dione (20.4 g, 125.0 mmoL), benzyl bromide (17.8 mL, 150 mmoL) and 20.8 g, 75 mmoL) in toluene (250 mL) was stirred at room temperature for 3 days under the protection from light. The reaction was stopped, filtered through celite and rinsed with a mixture of methylene chloride and methanol. The filtrate was concentrated and trituated in petroleum ether (150 mL). Filtration of the mixture provided the desired product (29.4 g, 92%).

後処理

  1. filtrationfiltered through celite
  2. washrinsed with a mixture of methylene chloride and methanol
  3. concentrationThe filtrate was concentrated
  4. filtrationFiltration of the mixture

出典と根拠

ORDレコード
ord-04894738ec954b35b3d7e61e2b6cf196
出典データセット
uspto-grants-2009_10
特許番号
US07605265B2

反応ノート

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