tert-Butylhydrazine monohydrochloride → 1-tert-Butyl-5-(4-nitrophenyl)-1H-pyrazole

反応式

CC(C([N:9]1[CH:13]=[C:12](B2OC(C)(C)C(C)(C)O2)[C:11]([C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=2)=[N:10]1)C([O-])=O)(C)C.Cl.[C:33](NN)([CH3:36])([CH3:35])[CH3:34]>>[CH3:34][C:33]([N:10]1[C:11]([C:23]2[CH:24]=[CH:25][C:26]([N+:29]([O-:31])=[O:30])=[CH:27][CH:28]=2)=[CH:12][CH:13]=[N:9]1)([CH3:36])[CH3:35]

参加物

反応物 2

HCID 81889tert-Butylhydrazine monohydrochloride

HCID 69001014HCID 69001014、化合物

生成物 1

HCID 534855271-tert-Butyl-5-(4-nitrophenyl)-1H-pyrazole

実験手順

Following the procedure described for Intermediate 1 with t-butylhydrazine hydrochloride, provided the title compound as the major isomer (80%). ESMS (M-C(CH3)3+2H): 190.0; HNMR (400 MHz, d6-DMSO) 8.32 (d, 2H), 7.7 (d, 2H), 7.48 (d, 1H), 6.25 (d, 1H), 1.42 (s, 9H)

出典と根拠

ORDレコード: ord-08c15956af524efe9779a5a97d77aa88
出典データセット: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07605266B2

反応ノート

読み込み中…