Potassium Carbonate → Methyl (4-formyl-2-methoxy-3-nitrophenoxy)acetate

HRID 1821432ノート

反応式

HRID 1821432 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:13][CH3:14].Br[CH2:16][C:17]([O:19][CH3:20])=[O:18].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:6]([C:5]1[CH:8]=[CH:9][C:2]([O:1][CH2:16][C:17]([O:19][CH3:20])=[O:18])=[C:3]([O:13][CH3:14])[C:4]=1[N+:10]([O-:12])=[O:11])=[O:7]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 96959Benzaldehyde, 4-hydroxy-3-methoxy-2-nitro-

生成物 1

HCID 86628221Methyl (4-formyl-2-methoxy-3-nitrophenoxy)acetate収率 84%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 4-hydroxy-3-methoxy-2-nitrobenzaldehyde (2.0 g, 10 mmol) in DMF (10 mL) was added with methyl bromoacetate (1.1 mL, 11 mmol) and potassium carbonate (2.1 g, 15 mmol), followed by stirring for 1.5 hours. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (chloroform/methanol=9/1) to obtain methyl (4-formyl-2-methoxy-3-nitrophenoxy)acetate (2.2 g, 84%).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (chloroform/methanol=9/1)

出典と根拠

ORDレコード
ord-75b5dd46d1a94d4da39fbfbfbe008008
出典データセット
uspto-grants-2009_10
特許番号
US07605272B2

反応ノート

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