hydroxylamine-O-sulfonic acid → 1,3-Benzenedicarbonitrile, 4-fluoro-
反応式
[F:1][C:2]1[CH:9]=[CH:8][C:7]([CH:10]=O)=[CH:6][C:3]=1[C:4]#[N:5].[NH2:12]OS(O)(=O)=O>O>[F:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]#[N:12])=[CH:6][C:3]=1[C:4]#[N:5]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of 2-fluoro-5-formylbenzonitrile (5.1 g, 33.9 mmol) in water (75 ml) was added hydroxylamine-O-sulphonic acid (4.6 g, 40.7 mmol) and the reaction mixture was heated at 50° C. for 5 h. The mixture was filtered and the solid material was washed with water and dried in vacuo for 18 h to give the title compound (4.3 g)
後処理
- filtrationThe mixture was filtered
- washthe solid material was washed with water
- customdried in vacuo for 18 h
出典と根拠
- ORDレコード
- ord-cef91c3e4cb54f378394874c12c3c473
- 出典データセット
- uspto-grants-2009_10
- 特許番号
- US07608604B2
反応ノート
読み込み中…