Formic Acid → 6-Bromo-4-azabenzimidazole
反応式
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH:10](O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[CH:10][NH:8][C:5]2=[N:6][CH:7]=1参加物
3
実験手順
5-Bromo-2,3-diaminopyridine (1.69 g, 8.99 mmole) was taken up in 96% formic acid (50 mL) and heated to reflux. After 18 hr the mixture was cooled to RT and concentrated. The residue was taken up in H2O and the pH was adjusted to 7 with 2.0 M NaOH. The title compound (1.54 g, 87%) was collected as a solid by filtration, washed with H2O, and dried in vacuo: MS (ES) m/e 198/200 (M+H)+.
後処理
- temperatureheated to reflux
- concentrationconcentrated
- filtrationThe title compound (1.54 g, 87%) was collected as a solid by filtration
- washwashed with H2O
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-927531f2479049d7b1a9c998d4269d4f
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741339B2
反応ノート
読み込み中…