Formic Acid → 6-Bromo-4H-imidazo[4,5-b]pyridine

HRID 18216

反応式

HRID 18216 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH:10](O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[CH:10][NH:8][C:5]2=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 284Formic AcidHCID 6911565-Bromopyridine-2,3-diamine

生成物 1

HCID 9115786-Bromo-4H-imidazo[4,5-b]pyridine

実験手順

5-Bromo-2,3-diaminopyridine (1.69 g, 8.99 mmole) was taken up in 96% formic acid (50 mL) and heated to reflux. After 18 hr the mixture was cooled to RT and concentrated. The residue was taken up in H2O and the pH was adjusted to 7 with 2.0 M NaOH. The title compound (1.54 g, 87%) was collected as a solid by filtration, washed with H2O, and dried in vacuo: MS (ES) m/e 198/200 (M+H)+.

後処理

  1. temperatureheated to reflux
  2. concentrationconcentrated
  3. filtrationThe title compound (1.54 g, 87%) was collected as a solid by filtration
  4. washwashed with H2O
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-927531f2479049d7b1a9c998d4269d4f
出典データセット
uspto-grants-2010_06
特許番号
US07741339B2

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