2-Benzoyl-4-ethylphenol → 3-{4-[3-(2-Benzoyl-4-ethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid

HRID 1822259

反応式

HRID 1822259 の反応式
C[O:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15](Br)[CH:14]=2)=[CH:8][C:7]=1[CH3:20].[CH2:22]([C:24]1[CH:25]=[CH:26][C:27]([OH:38])=[C:28]([C:30]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[O:31])[CH:29]=1)[CH3:23]>>[C:30]([C:28]1[CH:29]=[C:24]([CH2:22][CH3:23])[CH:25]=[CH:26][C:27]=1[O:38][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=1)[O:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][C:3]([OH:2])=[O:21])=[C:7]([CH3:20])[CH:8]=1)(=[O:31])[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

参加物

3

反応物 2

HCID 131496532-Benzoyl-4-ethylphenolHCID 578941923-[4-(3-Bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester

生成物 1

HCID 114544553-{4-[3-(2-Benzoyl-4-ethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid

実験手順

The title compound is prepared by reacting the compound of 3-[4-(3-bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester with (5-ethyl-2-hydroxy-phenyl)-phenyl-methanone as in Example 18 to afford 0.220 g (50%). 1H NMR (400 MHz, CDCl3); HRMS (ES+) m/z exact mass calculated for C31H28O5 481.2015, found 481.2032 (M+1).

後処理

  1. customto afford 0.220 g (50%)

出典と根拠

ORDレコード
ord-024fe1fc878c4d65aa0b107947a9a4bb
出典データセット
uspto-grants-2009_10
特許番号
US07608639B2

関連ノート

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