Methyl 3-(4-Hydroxy-2-methylphenyl)propanoate → 3-[4-(3-Bromo-5-ethyl-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester
反応式
Br[C:2]1[CH:7]=[C:6]([CH2:8][CH3:9])[CH:5]=[C:4]([Br:10])[CH:3]=1.[CH3:11][O:12][C:13](=[O:24])[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][C:17]=1[CH3:23]>>[CH3:11][O:12][C:13](=[O:24])[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][C:2]2[CH:7]=[C:6]([CH2:8][CH3:9])[CH:5]=[C:4]([Br:10])[CH:3]=2)=[CH:18][C:17]=1[CH3:23]参加物
3
実験手順
Compound of 1,3-dibromo-5-ethyl-benzene is reacted with 3-(4-hydroxy-2-methyl-phenyl)-propionic acid methyl ester as in Example 18 to afford 0.898 g (56%) of the title compound. Rf=0.32 (4/1 hexanes/EtOAc). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calculated for C19H21O3Br 376, found 377 and 379 (M+1 and M+3, 100%).
出典と根拠
- ORDレコード
- ord-a04c183c065641e1894daba96423362a
- 出典データセット
- uspto-grants-2009_10