4-Fluoro-2-methylaniline → 4-(4-Fluoro-2-methylanilino)-6-methoxy-3-quinolinecarboxamide

HRID 1822859ノート

反応式

HRID 1822859 の反応式
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[CH:17][C:16]([C:22]([NH2:24])=[O:23])=[C:15]2Cl.C(O)(=O)C.C(O)C>C(O)C>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:15]2[C:14]3[C:19](=[CH:20][CH:21]=[C:12]([O:11][CH3:10])[CH:13]=3)[N:18]=[CH:17][C:16]=2[C:22]([NH2:24])=[O:23])=[C:4]([CH3:9])[CH:3]=1

参加物

5

反応物 3

HCID 679824-Fluoro-2-methylanilineHCID 18476134Acetic acid ethanolHCID 221702744-Chloro-6-methoxyquinoline-3-carboxamide

生成物 1

HCID 221703694-(4-Fluoro-2-methylanilino)-6-methoxy-3-quinolinecarboxamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4-fluoro-2-methylaniline (0.025 mmol), 6-methoxy-4-chloro-3-quinolinecarboxamide (0.025 mmol), 50 μl 20% Acetic acid/Ethanol and 250 μl ethanol was refluxed for four hours. After cooling to room temperature the solvent was removed in vacuu.

後処理

  1. temperaturewas refluxed for four hours
  2. customwas removed in vacuu

出典と根拠

ORDレコード
ord-101c64c03e9c44128660c91cd299617e
出典データセット
uspto-grants-2006_05
特許番号
US07037925B2

反応ノート

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