2-Bromophenylacetic acid → HCID 22170862、化合物

反応式

C1(N=C=N)CCCCC1.[Br:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][C:18]([OH:20])=O.[NH2:21][C:22]1[S:23][C:24]([CH:27]([CH3:29])[CH3:28])=[CH:25][N:26]=1>C(Cl)Cl>[CH:27]([C:24]1[S:23][C:22]([NH:21][C:18](=[O:20])[CH2:17][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[Br:10])=[N:26][CH:25]=1)([CH3:29])[CH3:28]

参加物

実験手順

To a suspension of resin N-Cyclohexylcarbodiimide N′-methylpolystyrene (0.251 g, 2.39 mmol g, 0.6 mmol), previously washed with DCM (3×5 ml), in DCM (4 ml) at room temperature, 2-bromophenylacetic acid (0.086 g, 0.4 mmol) was added. After 10 min., a solution of 2-amino-5-isopropyl-1,3-thiazole (0.0284 g, 0.2 mmol) in DCM (4 ml) was added. The mixture was shaked for 24 hours at room temperature, the resin filtered and washed with DCM (3×10 ml). The filtrated were combined, washed with water, 5% HCl, water, saturated sodium bicarbonate and water, dried over sodium sulfate and evaporated.