Acetic Anhydride → Acetamide, N-(4-hydroxy-2,5-dimethylphenyl)-

HRID 1822898

反応式

HRID 1822898 の反応式
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([CH3:10])[CH:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>O>[OH:9][C:5]1[C:4]([CH3:10])=[CH:3][C:2]([NH:1][C:11](=[O:13])[CH3:12])=[C:7]([CH3:8])[CH:6]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 765444-Amino-2,5-dimethylphenol

生成物 1

HCID 155307Acetamide, N-(4-hydroxy-2,5-dimethylphenyl)-収率 90.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

To a suspension of 4-amino-2,5-dimethyl-phenol (6.85 g, 50 mmol) in 30 mL of water was added acetic anhydride (5.67 mL, 60 mmol). The mixture was vigorously stirred at 70° C. for 20 min and then cooled down to room temperature. The solid was collected by filtration and washed with water to give N-(4-hydroxy-2,5-dimethyl-phenyl)-acetamide as gray solid (8.1 g, 90%).

後処理

  1. temperaturecooled down to room temperature
  2. filtrationThe solid was collected by filtration
  3. washwashed with water

出典と根拠

ORDレコード
ord-319565c3bd714555a2d8cd31a5c25312
出典データセット
uspto-grants-2006_05
特許番号
US07037909B2

関連ノート

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