Water → 4-Chloro-N-hydroxy-3-pyridinecarboximidoyl chloride

HRID 1823277ノート

反応式

HRID 1823277 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[CH:8]=[N:9][OH:10].[Cl:11]N1C(=O)CCC1=O.O>CN(C)C=O>[Cl:11][C:8]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:2]=1[Cl:1])=[N:9][OH:10]

参加物

5

反応物 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 57365610HCID 57365610、化合物

生成物 1

HCID 738675804-Chloro-N-hydroxy-3-pyridinecarboximidoyl chloride収率 75.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Dissolve 4-chloropyridine-3-carboxaldehyde oxime (2.60 g, 0.017 mol) in N,N-dimethylformamide (20 mL). Add N-chlorosuccinimide (2.48 g, 0.018 mol) in small portions and stir overnight at ambient temperature. Pour the mixture into water and extract with ethyl acetate. Wash the combined extracts with water and dry over sodium sulfate. Concentrate in vacuo to give 2.45 g (75%) of crude product as a yellowish solid. 1H NMR was consistent with structure.

後処理

  1. extractionextract with ethyl acetate
  2. washWash the combined extracts with water
  3. dry with materialdry over sodium sulfate
  4. concentrationConcentrate in vacuo

出典と根拠

ORDレコード
ord-bfd19997605e4ea5a3112a30a94f813e
出典データセット
uspto-grants-2006_05
特許番号
US07037921B2

反応ノート

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