Sodium Carbonate → 3-benzyl-2-isobutyl-3H-pteridin-4-one

関与物質

反応手順

Formula 104 where R2 and R3 are H; R5 is Benzyl; R6 is Isopropyl; R6′ is H; X and Y are —C═; and W and Z are —N═: A solution of DMF (100 mL), 3-(3-methyl-butyrylamino)-pyrazine-2-carboxylic acid benzylamide (3.0 g, 9.60 mmol) and sodium carbonate (1.30 g, 12.3 mmol) was stirred at 120° C. overnight. The solvent was removed under reduced pressure and the residue purified by silica gel chromatography using hexane-EtOAc (2:1) as eluent to obtain the desired pyrazopyrimidinone product of Formula 104, 3-benzyl-2-isobutyl-3H-pteridin-4-one (0.948 g, 33.0%). MS (Cl) M/E: 295.1.

情報源と証拠